financial engineering at its best. this is what we need, not dudebros playing with other people's money. i'd gladly slash & burn 90% of finance if we can retain the useful 10%, like this.

2024-09-10: Scientific Duplication Crisis

Saloni Dattani and Rachel Meager document academic science's widespread duplication crisis: researchers across biomedicine and economics routinely execute redundant, uncoordinated clinical trials and observational studies that waste billions in research capital. Establishing shared global trial registries and meta-analytical clearinghouses is required to redirect funding toward unexplored frontiers. worksinprogress.news

2024-11-10: Human Challenge Trial Ethics

Empirical risk data from human challenge trials demonstrates that controlled volunteer infections present hospitalization and fatality risks lower than standard Phase III clinical trials, exposing institutional IRB risk aversion that delays vaccine rollouts during acute pandemics. marginalrevolution.com

2026-07-10: Phase II Clinical Attrition

Thirty years of clinical attrition data shows Phase II clinical efficacy failure rates remain fixed at 85–90% despite revolutions in structural biology and screening: human in vivo biological complexity and target validation remain the dominant bottlenecks in medicine. science.org