The hope is that the next time there’s an outbreak, within 2 days, we’ll have models of candidates
2023-07-10: Generative Protein Diffusion
Generative diffusion models (RFdiffusion) decouple molecular engineering from natural evolutionary templates, hallucinating bespoke binders, enzymes, and catalytic sites from sequence noise with sub-angstrom precision rather than merely predicting the static folds of existing natural proteins. science.org
2024-07-10: ESM3 Generative Biology
EvolutionaryScale introduced ESM3, a 98-billion-parameter multimodal generative biological model reasoning simultaneously over protein sequence, structure, and active-site function. ESM3 designed ESMGFP, a novel green fluorescent protein requiring 500 million years of simulated evolutionary divergence to fold and fluoresce, establishing generative AI as a primary engine for programmable synthetic biology. nature.com